Publications
Mishra, S., Cosentino, C., Tamta, A.K. et al. Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling. Nat Commun 13, 5415 (2022). https://doi.org/10.1038/s41467-022-32905-w
Khan, D., Ara, T., Ravi, V., Rajagopal, R., Tandon, H., Parvathy, J., Gonzalez, E. A., Asirvatham-Jeyaraj, N., Krishna, S., Mishra, S., Raghu, S., Bhati, A. S., Tamta, A. K., Dasgupta, S., Kolthur-Seetharam, U., Etchegaray, J. P., Mostoslavsky, R., Rao, P., Srinivasan, N., & Sundaresan, N. R. (2021). SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ. Cell reports, 35(9), 109190. 10.1016/j.celrep.2021.109190
Ravi, V., Jain, A., Taneja, A., Chatterjee, K., & Sundaresan, N. R. (2021). Isolation and culture of neonatal murine primary cardiomyocytes. Current Protocols, 1, e196. doi: 10.1002/cpz1.196
Ravi, V., Mishra, S., & Sundaresan, N. R. (2021). Role of sirtuins in cardiovascular diseases. In Sirtuin Biology in Medicine (pp. 261–284). Academia Press. https://doi.org/10.1016/B978-0-12-814118-2.00021-5
Mishra, S., Ravi, V., & Sundaresan, N. R. (2021). Role of FoxO transcription factors in aging-associated cardiovascular diseases. Vitamins and Hormones, 449–475. https://doi.org/10.1016/bs.vh.2020.12.018
A Jain, M Behera, V Ravi, S Mishra, NR Sundaresan, K Chatterjee. Recapitulating pathophysiology of skeletal muscle diseases in vitro using primary mouse myoblasts on a nanofibrous platform. Nanomedicine: Nanotechnology, Biology and Medicine. 2021
Dhandapany PS, Kang S, Kashyap DK, Rajagopal R, Sundaresan NR, Singh R, Thangaraj K, Jayaprakash S, Manjunath CN, Shenthar J, Lebeche D. Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin. Sci Adv. 2021 Jan 6
Ravi, V., Jain, A., Mishra, S., & Sundaresan, N. R. (2020). Measuring Protein Synthesis in Cultured Cells and Mouse Tissues Using the Non‐radioactive SUnSET Assay. Current Protocols in Molecular Biology. 133, e127.
Subramanian, PSG, Jain, A, Shivapuji, AM, Sundaresan, NR, Dasappa, S, Rao, L. Plasma‐activated water from a dielectric barrier discharge plasma source for the selective treatment of cancer cells. Plasma Process Polym. 2020
Maity S, Muhamed J, Sarikhani M, Kumar S, Ahamed F, Spurthi KM, Ravi V, Jain A, Khan D, Arathi BP, Desingu PA, Sundaresan NR. Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice. J Biol Chem. 2020 Jan 10
Ravi V, Jain A, Khan D, Ahamed F, Mishra S, Giri M, Inbaraj M, Krishna S, Sarikhani M, Maity S, Kumar S, Shah RA, Dave P, Pandit AS, Rajendran R, Desingu PA, Varshney U, Das S, Kolthur-Seetharam U, Rajakumari S, Singh M, Sundaresan NR. SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity. Nucleic Acids Res. 2019 Aug 2
Gogoi M, Chandra, Sarikhani M, Ramani R, Sundaresan NR, Chakravortty D.Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells. PLoS Pathog 14 2018
Talakatta G, Sarikhani M, Muhamed J, Dhanya K, Somashekar BS, Mahesh PA, Sundaresan N, Ravindra PV. Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways. Scientific Reports. 9th August 2018.
Subramanian G, Kumar GSS, Ravi V, Sundaresan NR and Madras G. Photochemical detoxification of Cr(VI) using iron and saccharic acid: insights from cytotoxic and genotoxic assays. Environmental Science: Water Research and Technology. 1st June 2018.
Spurthi KM, Sarikhani M, Mishra S, Desingu PA, Yadav S, Rao S, Maity S, Tamta AK, Kumar S, Majumdar S, Jain A, Raghuraman A, Khan D, Singh I, Samuel RJ, Ramachandra SG, Nandi D, Sundaresan NR. Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. Journal of Biological Chemistry. 21st June 2018.
Mishra S, Tamta AK, Sarikhani M, Desingu PA, Kizkekra SM, Shriniwas PA, Kumar S, Khan D, Raghavan SC, Sundaresan NR. Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy. Scientific Reports. 4th April 2018.
Ghosh LD, Jain A, Sundaresan NR, Chatterjee K: Elucidating molecular events underlying topography mediated cardiomyogenesis of stem cells on 3D nanofibrous scaffolds. Materials Science and Engineering C. 15th March 2018
Ravi V, Jain A, Ahamed F, Fathma N, Desingu PA, Sundaresan NR. Systematic evaluation of the adaptability of the non-radioactive SUnSET assay to measure cardiac protein synthesis. Scientific Reports. 15th March 2018
Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. eLife. 5th March 2018.
Jain A, Hasan J, Desingu PA, Sundaresan NR, Chatterjee K: “Engineering an in vitro organotypic model for studying cardiac hypertrophy” Colloids and Surfaces B: Biointerfaces 2018: 14 February 2018
Sarikhani M, Mishra S, Desingu PA, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase. Cell, Death and Differentiation. 15 February 2018
Sarikhani M, Maity S, Mishra S, Jain A, Tamta AK, Ravi V, Spurthi KM, Desingu PA, Khan D, Kumar S, Rao S, Inbaraj M, Shriniwas PA, Sundaresan NR. SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis. Journal of Biological Chemistry. 13 February 2018
Khan D, Sarikhani M, Dasgupta S, Maniyadath B, Pandit AS, Mishra S, Ahamed F, Dubey A, Fathma N, Atreya HS, Kolthur-Seetharam U, Sundaresan NR. SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart. Journal of Cellular Physiology, 10 January 2018.
Yadav S, Pathak S, Sarikhani M, Majumdar S, Ray S, Chandrasekar BS, Adiga V, Sundaresan NR, Nandi D. Nitric oxide synthase 2 enhances the survival of mice during Salmonella Typhimurium infection-induced sepsis by increasing reactive oxygen species, inflammatory cytokines and recruitment of neutrophils to the peritoneal cavity. Free Radical Biology and Medicine. 2018 Feb 20;116:73-87. [PMID: 29309892]
Jain A, Ravi V, Muhamed J, Chatterjee K, Sundaresan NR. A simplified protocol for culture of murine neonatal cardiomyocytes on nanoscale keratin coated surfaces. International Journal of Cardiology, 2017 Apr 1;232:160-170. [PMID: 28096043]
Ghosh LD, Ravi V, Sanpui P, Sundaresan NR, Chatterjee K. Keratin mediated attachment of stem cells to augment cardiomyogenic lineage commitment. Colloids and Surfaces B: Biointerfaces Volume 151, 1 March 2017, Pages 178–188.
Gautam R, Deobagkar-Lele M, Majumdar S, Chandrasekar B, Victor E, Ahmed SM, Wadhwa N, Verma T, Kumar S, Sundaresan NR, Umapathy S, Nandi D. Molecular profiling of sepsis in mice using Fourier Transform Infrared Microspectroscopy. J Biophotonics. 2016 Jan; 9(1-2):67-82. [PMID:25808727]
Sundaresan NR, Bindu S, Pillai VB, Samant S, Pan Y, Huang JY, Gupta M, Nagalingam RS, Wolfgeher D, Verdin E, Gupta MP. SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3β. Mol Cell Biol. 2016 March. pii: MCB.00586-15. [PMID:26667039]
Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D, Gupta MP. Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nature Comm. 2015 Apr 14; 6:6656. [PMID:25871545]
Ming M, Han W, Zhao B, Sundaresan NR, Deng CX, Gupta MP, He YY. SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res. 2014 Oct 15; 74(20):5925-33. [PMID:25320180]
Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevananadam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nature Medicine 2012, 18(11):1643-50.
Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Gupta MP, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M Gupta MP. SIRT1 regulates Akt and PDK1 membrane localization and activation during cell growth associated with tumorigenesis and cardiac hypertrophy. Science Signaling 2011, 4(182):ra46.
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. Journal of Clinical Investigation 2009, 119(9):2758-71.
For the full list, please visit PUBMED here
Mishra, S., Cosentino, C., Tamta, A.K. et al. Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling. Nat Commun 13, 5415 (2022). https://doi.org/10.1038/s41467-022-32905-w
Khan, D., Ara, T., Ravi, V., Rajagopal, R., Tandon, H., Parvathy, J., Gonzalez, E. A., Asirvatham-Jeyaraj, N., Krishna, S., Mishra, S., Raghu, S., Bhati, A. S., Tamta, A. K., Dasgupta, S., Kolthur-Seetharam, U., Etchegaray, J. P., Mostoslavsky, R., Rao, P., Srinivasan, N., & Sundaresan, N. R. (2021). SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ. Cell reports, 35(9), 109190. 10.1016/j.celrep.2021.109190
Ravi, V., Jain, A., Taneja, A., Chatterjee, K., & Sundaresan, N. R. (2021). Isolation and culture of neonatal murine primary cardiomyocytes. Current Protocols, 1, e196. doi: 10.1002/cpz1.196
Ravi, V., Mishra, S., & Sundaresan, N. R. (2021). Role of sirtuins in cardiovascular diseases. In Sirtuin Biology in Medicine (pp. 261–284). Academia Press. https://doi.org/10.1016/B978-0-12-814118-2.00021-5
Mishra, S., Ravi, V., & Sundaresan, N. R. (2021). Role of FoxO transcription factors in aging-associated cardiovascular diseases. Vitamins and Hormones, 449–475. https://doi.org/10.1016/bs.vh.2020.12.018
A Jain, M Behera, V Ravi, S Mishra, NR Sundaresan, K Chatterjee. Recapitulating pathophysiology of skeletal muscle diseases in vitro using primary mouse myoblasts on a nanofibrous platform. Nanomedicine: Nanotechnology, Biology and Medicine. 2021
Dhandapany PS, Kang S, Kashyap DK, Rajagopal R, Sundaresan NR, Singh R, Thangaraj K, Jayaprakash S, Manjunath CN, Shenthar J, Lebeche D. Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin. Sci Adv. 2021 Jan 6
Ravi, V., Jain, A., Mishra, S., & Sundaresan, N. R. (2020). Measuring Protein Synthesis in Cultured Cells and Mouse Tissues Using the Non‐radioactive SUnSET Assay. Current Protocols in Molecular Biology. 133, e127.
Subramanian, PSG, Jain, A, Shivapuji, AM, Sundaresan, NR, Dasappa, S, Rao, L. Plasma‐activated water from a dielectric barrier discharge plasma source for the selective treatment of cancer cells. Plasma Process Polym. 2020
Maity S, Muhamed J, Sarikhani M, Kumar S, Ahamed F, Spurthi KM, Ravi V, Jain A, Khan D, Arathi BP, Desingu PA, Sundaresan NR. Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice. J Biol Chem. 2020 Jan 10
Ravi V, Jain A, Khan D, Ahamed F, Mishra S, Giri M, Inbaraj M, Krishna S, Sarikhani M, Maity S, Kumar S, Shah RA, Dave P, Pandit AS, Rajendran R, Desingu PA, Varshney U, Das S, Kolthur-Seetharam U, Rajakumari S, Singh M, Sundaresan NR. SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity. Nucleic Acids Res. 2019 Aug 2
Gogoi M, Chandra, Sarikhani M, Ramani R, Sundaresan NR, Chakravortty D.Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells. PLoS Pathog 14 2018
Talakatta G, Sarikhani M, Muhamed J, Dhanya K, Somashekar BS, Mahesh PA, Sundaresan N, Ravindra PV. Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways. Scientific Reports. 9th August 2018.
Subramanian G, Kumar GSS, Ravi V, Sundaresan NR and Madras G. Photochemical detoxification of Cr(VI) using iron and saccharic acid: insights from cytotoxic and genotoxic assays. Environmental Science: Water Research and Technology. 1st June 2018.
Spurthi KM, Sarikhani M, Mishra S, Desingu PA, Yadav S, Rao S, Maity S, Tamta AK, Kumar S, Majumdar S, Jain A, Raghuraman A, Khan D, Singh I, Samuel RJ, Ramachandra SG, Nandi D, Sundaresan NR. Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. Journal of Biological Chemistry. 21st June 2018.
Mishra S, Tamta AK, Sarikhani M, Desingu PA, Kizkekra SM, Shriniwas PA, Kumar S, Khan D, Raghavan SC, Sundaresan NR. Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy. Scientific Reports. 4th April 2018.
Ghosh LD, Jain A, Sundaresan NR, Chatterjee K: Elucidating molecular events underlying topography mediated cardiomyogenesis of stem cells on 3D nanofibrous scaffolds. Materials Science and Engineering C. 15th March 2018
Ravi V, Jain A, Ahamed F, Fathma N, Desingu PA, Sundaresan NR. Systematic evaluation of the adaptability of the non-radioactive SUnSET assay to measure cardiac protein synthesis. Scientific Reports. 15th March 2018
Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. eLife. 5th March 2018.
Jain A, Hasan J, Desingu PA, Sundaresan NR, Chatterjee K: “Engineering an in vitro organotypic model for studying cardiac hypertrophy” Colloids and Surfaces B: Biointerfaces 2018: 14 February 2018
Sarikhani M, Mishra S, Desingu PA, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase. Cell, Death and Differentiation. 15 February 2018
Sarikhani M, Maity S, Mishra S, Jain A, Tamta AK, Ravi V, Spurthi KM, Desingu PA, Khan D, Kumar S, Rao S, Inbaraj M, Shriniwas PA, Sundaresan NR. SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis. Journal of Biological Chemistry. 13 February 2018
Khan D, Sarikhani M, Dasgupta S, Maniyadath B, Pandit AS, Mishra S, Ahamed F, Dubey A, Fathma N, Atreya HS, Kolthur-Seetharam U, Sundaresan NR. SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart. Journal of Cellular Physiology, 10 January 2018.
Yadav S, Pathak S, Sarikhani M, Majumdar S, Ray S, Chandrasekar BS, Adiga V, Sundaresan NR, Nandi D. Nitric oxide synthase 2 enhances the survival of mice during Salmonella Typhimurium infection-induced sepsis by increasing reactive oxygen species, inflammatory cytokines and recruitment of neutrophils to the peritoneal cavity. Free Radical Biology and Medicine. 2018 Feb 20;116:73-87. [PMID: 29309892]
Jain A, Ravi V, Muhamed J, Chatterjee K, Sundaresan NR. A simplified protocol for culture of murine neonatal cardiomyocytes on nanoscale keratin coated surfaces. International Journal of Cardiology, 2017 Apr 1;232:160-170. [PMID: 28096043]
Ghosh LD, Ravi V, Sanpui P, Sundaresan NR, Chatterjee K. Keratin mediated attachment of stem cells to augment cardiomyogenic lineage commitment. Colloids and Surfaces B: Biointerfaces Volume 151, 1 March 2017, Pages 178–188.
Gautam R, Deobagkar-Lele M, Majumdar S, Chandrasekar B, Victor E, Ahmed SM, Wadhwa N, Verma T, Kumar S, Sundaresan NR, Umapathy S, Nandi D. Molecular profiling of sepsis in mice using Fourier Transform Infrared Microspectroscopy. J Biophotonics. 2016 Jan; 9(1-2):67-82. [PMID:25808727]
Sundaresan NR, Bindu S, Pillai VB, Samant S, Pan Y, Huang JY, Gupta M, Nagalingam RS, Wolfgeher D, Verdin E, Gupta MP. SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3β. Mol Cell Biol. 2016 March. pii: MCB.00586-15. [PMID:26667039]
Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D, Gupta MP. Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nature Comm. 2015 Apr 14; 6:6656. [PMID:25871545]
Ming M, Han W, Zhao B, Sundaresan NR, Deng CX, Gupta MP, He YY. SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res. 2014 Oct 15; 74(20):5925-33. [PMID:25320180]
Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevananadam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nature Medicine 2012, 18(11):1643-50.
Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Gupta MP, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M Gupta MP. SIRT1 regulates Akt and PDK1 membrane localization and activation during cell growth associated with tumorigenesis and cardiac hypertrophy. Science Signaling 2011, 4(182):ra46.
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. Journal of Clinical Investigation 2009, 119(9):2758-71.
For the full list, please visit PUBMED here