About The Lab
Research in our lab focuses on post translational modifications by two families of NAD-dependent enzymes - Sirtuins and Poly (ADP-ribose) Polymerase (PARP). We try to find out how they regulate the pathophysiology of diseases in the heart and skeletal muscle. We use primary and secondary cell cultures as well as transgenic, dietary and surgical mouse models to test these enzymes for their ability to protect against metabolic disease. Our lab techniques range from physiology and biochemistry, to molecular biology and proteomics. We also take full advantage of the interdisciplinary network at IISc and other receptive collaborators. Ongoing work in our lab involves studies of the role of these enzymes in cardiac hypertrophy, fibrosis, mitochondrial dysfunction and muscle degeneration. Our goal is to uncover new biological functions of these enzymes that can be therapeutically targeted for promoting better health.
Keywords - Sirtuin, PARP, cardiovascular, muscle, signaling, disease
Research in our lab focuses on post translational modifications by two families of NAD-dependent enzymes - Sirtuins and Poly (ADP-ribose) Polymerase (PARP). We try to find out how they regulate the pathophysiology of diseases in the heart and skeletal muscle. We use primary and secondary cell cultures as well as transgenic, dietary and surgical mouse models to test these enzymes for their ability to protect against metabolic disease. Our lab techniques range from physiology and biochemistry, to molecular biology and proteomics. We also take full advantage of the interdisciplinary network at IISc and other receptive collaborators. Ongoing work in our lab involves studies of the role of these enzymes in cardiac hypertrophy, fibrosis, mitochondrial dysfunction and muscle degeneration. Our goal is to uncover new biological functions of these enzymes that can be therapeutically targeted for promoting better health.
Keywords - Sirtuin, PARP, cardiovascular, muscle, signaling, disease
Recent news
2022:
2017:
2022:
- 24.08.22: Congratulations Dr. Sneha Mishra et al. for acceptance of their manuscript 'Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal 6 muscle atrophy by regulating IGF/PI3K/AKT signaling' in Nature Communications
- 01.06.2022: Congratulations Prof. Ravi Sundaresan for getting elected as a member of the Guha Research Conference Association
- 18.03.2022: Congratulations Aastha Munjal and Krishnega Murugasamy for their literature review article 'Emerging Roles of SIRT3 in Cardiac Metabolism' published in Frontiers in Cardiovascular Medicine
- 28.09.2021: Congratulations Arushi Taneja et al. for their literature review article 'Emerging roles of Sirtuin 2 in cardiovascular diseases' published in the FASEB journal
- 01.09.2021: Congratulations Sukanya Raghu et al. for their book chapter 'Sirtuin 6 Is a Critical Epigenetic Regulator of Cancer' published in the book Metabolism and Epigenetic Regulation: Implications in Cancer by Springer
- 21.07.21: Congratulations Dr. Dr. Venkatraman Ravi et al. for their protocol paper 'Isolation and culture of neonatal murine primary Cardiomyocytes' published in Current Protocols
- 01.06.2021: Congratulations Dr. Danish Khan et al. for the manuscript 'SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ' published in Cell Reports
- 01.05.2021: Congratulations Dr. Danish Khan for securing a Post Doc position at Leiden University
- 13.02.2021: Congratulations Dr. Sneha Mishra and Dr. Venkatraman Ravi for their book chapter Role of FoxO transcription factors in aging-associated cardiovascular diseases published in the book Vitamins and Hormones by Elsevier press
- 06.01.2021: Congratulations Raksha Rajagopal for co-author manuscript in Science Advances
- 01.01.2021: Congratulations Dr. Venkatraman Ravi and Dr. Sneha Mishra for their book chapter Role of sirtuins in cardiovascular diseases published in the book Sirtuin Biology in Medicine by Academic Press
- 01.01.2021: Congratulations Dr. Venkatraman Ravi for being awarded the Sreenivasaya Medal for the Best Thesis by the Indian Institute of Science
- 20.11.2020: Congratulations Dr. Venkatraman Ravi, Aditi Jain, and Dr. Sneha Mishra for their manuscript Measuring Protein Synthesis in Cultured Cells and Mouse Tissues Using the Non‐radioactive SUnSET Assay published in Current Protocols in Molecular Biology
- 10.11.2020: Congratulations Aditi Jain, Dr. Venkatraman Ravi and Dr. Sneha Mishra for manuscript accepted in Nanomedicine: Nanotechnology, Biology and Medicine.
- 11.09.2020: Congratulations Dr. Venkatraman Ravi for manuscript accepted in Current Protocols in Molecular Biology.
- 13.08.2020: Congratulations Aditi Jain for manuscript accepted in Materials Science and Engineering C.
- 02.04.2020: Congratulations Aditi Jain for co-author manuscript accepted in Plasma Processes and Polymers.
- 06.12.2019: Congratulations Dr. N. Ravi Sundaresan for being awarded National Bioscience Award for Career Development 2019.
- 22.11.2019: Congratulations Dr. Sangeeta and Dr. Jaseer et al. for acceptance of manuscript in Journal of Biological Chemistry.
- 30.09.2019: Congratulations Dr. N. Ravi Sundaresan for being awarded NASI-Scopus Young Scientist Award 2019 in the field of Biomedical Research and Healthcare.
- 25.09.2019: Congratulations Venkatraman Ravi for being awarded Travel fellowship from Microbiology and Cell Biology Society, IISc.
- 16.09.2019: Congratulations Lopamudra et al for manuscript accepted in Nanoscale.
- 13.09.2019: Congratulations Venkatraman Ravi for being awarded DST international travel grant (SERB) to attend the Cell Symposia: Transcriptional regulation in evolution, development and disease at Chicago, 20-22nd October 2019.
- 13.09.2019: Congratulations Mohsen for being awarded Institute medal for Best PhD thesis in Microbiology and Cell Biology.
- 07.09.2019: Congratulations Venkatraman Ravi for being awarded DBT international travel grant to attend the EMBO Workshop: Protein Synthesis and Translational Control at Heidelberg, Germany from 4-7th September 2019.
- 11.07.2019: Congratulations Venkatraman et al for manuscript accepted in Nucleic Acid Research.
- 11.07.2019: Congratulations Aditi for being awarded DST international travel grant (SERB) to attend the Basic Cardiovascular Scientific Sessions at Boston, 29th July -1st August 2019.
- 19.03.2019: Congratulations Lopamudra, Venkatraman and Aditi for manuscript accepted in Nanomedicine: Nanotechnology, Biology and Medicine.
- 13.11.2018: Congratulations Mohsen for co-author manuscript accepted in PLOS Pathogens.
- 22.10.2018: Congratulations Mohsen for co-author manuscript published in Scientific Reports.
- 28.07.2018: Congratulations Dr. Lopamudra Ghosh for ACS Award for best poster presentation at the BioMET 2018 Conference in Vellore
- 13.06.2018: Congratulations Dr. Spurthi et al for acceptance of manuscript in Journal of Biological Chemistry.
- 02.06.2018: Congratulations Venkatraman for acceptance of co-author manuscript in Environmental Science: Water Research & Technology.
- 14.04.2018: Congratulations Venkatraman getting the 1st runner up award at the KV Rao Scientific Society Research Award 2017-18 in the Biology stream.
- 15.03.2018: Congratulations Lopamudra et al for acceptance of manuscript in Materials Science and Engineering C.
- 08.03.2018: Congratulations Sneha et al for acceptance of manuscript in Scientific Reports.
- 02.03.2018: Congratulations Mohsen et al for manuscript accepted in eLife.
- 01.03.2018: Congratulations Venkatraman et al for manuscript accepted in Scientific Reports.
- 18.02.2018: Congratulations Shweta on getting the Best Oral Presentation Award (NS Dhalla Award) at the ISHR conference, Chandigarh, 16-18th Feb, 2018.
- 18.02.2018: Congratulations Aditi on getting the Best Poster Presentation Award at the ISHR conference, Chandigarh, 16-18th Feb, 2018.
- 14.02.2018: Congratulations Aditi for manuscript accepted in Colloids and Surfaces B: Biointerfaces.
- 13.02.2018: Congratulations Mohsen and Sangeeta et al for the manuscript ''SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis'' accepted in Journal of Biological Chemistry.
- 10.02.2018: Congratulations Venkatraman on getting the Devendra K. Agarwal Cash Award for Oral Presentation at the IACS conference, Madurai, 8-10th Feb 2018.
- 10.02.2018: Congratulations Dr. Spurthi on getting the NS Dhalla Cash Award for Poster Presentation at the IACS conference, Madurai, 8-10th Feb 2018.
- 15.01.2018: Congratulations Mohsen, Sneha and Designu for the manuscript accepted in Cell, Death and Differentation.
- 05.01.2018: Congratulations Danish et al for the manuscript "SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart" published in the Journal of Cellular Physiology.
- Congratulations Mohsen for co-author in the manuscript "Nitric oxide synthase 2 enhances the survival of mice during Salmonella Typhimurium infection-induced sepsis by increasing reactive oxygen species, inflammatory cytokines and recruitment of neutrophils to the peritoneal cavity" published in Free Radical Biology and Medicine.
- Congratulations Aditi for getting the Sun Pharma Science Foundation’s Science Scholar Awardee for the year 2017 in the field of Bio-Medical Sciences.
2017:
- Congratulations Venkatraman on getting the Young Scientist Award at the Second Annual Convention of the SVBBI 2017.
- Congratulations Aditi on getting the Best Oral Presentation Award at the Second Annual Convention of the SVBBI 2017.
- Congratulations Danish on getting the Best Poster Presentation Award at the International Society for Heart Research, Delhi 2017.
- Congratulations Aditi for the manuscript "A simplified protocol for culture of murine neonatal cardiomyocytes on nanoscale keratin coated surfaces" published in International Journal of Cardiology.
- Congratulations Lopamudra and Venkatraman for the manuscript Keratin Mediated Attachment of Stem Cells to Augment Cardiomyogenic Lineage Commitment published in Colloids and Surfaces B: Biointerfaces.
- Congratulations Nazeeha for securing PhD admisson at University of Queensland.
- Congratulations Veena for securing PhD admission at University of South Florida.
- Congratulations Jaseer for getting Scientist job in National institute of Occupational Health (NIOH)
We are funded by
The Department of Science and Technology (DST) , Government of India
The Department of Biotechnology (DBT), Government of India
The Council for Scientific and Industrial Research (CSIR)
The Indian Institute of Science, Bangalore
The Department of Science and Technology (DST) , Government of India
The Department of Biotechnology (DBT), Government of India
The Council for Scientific and Industrial Research (CSIR)
The Indian Institute of Science, Bangalore
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